Matthew 16:24-26 KJV
[24] Then said Jesus unto his disciples, If any man will come after me, let him deny himself, and take up his cross, and follow me.
[25] For whosoever will save his life shall lose it: and whosoever will lose his life for my sake shall find it.
[26] For what is a man profited, if he shall gain the whole world, and lose his own soul? or what shall a man give in exchange for his soul?
Jesus here was referring to selfishness when He said for people to deny themselves. They are to seek their wellbeing. If that were not true, they would not try to save their lives, but lose them. They would not seek profit, but shun it. They would choose to suffer the wrath of God, rather than be saved from it.
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